Background: Although the prevalence of complete tooth loss has declined over the last decade, edentulism remains a major disease worldwide, especially among older adults. Loss of vertical dimension of occlusion which causes reduction of the lower face height and rotation of the mandible are some of the conditions which may lead to obstructive sleep apnea. Aim of the study: To assess effect of Complete Dentures on Respiratory Performance: A spirometric analysis. Materials and methods: The present study was conducted in the Department Prosthodontics of the dental institution. The ethical clearance for the study was approved from the ethical committee of the hospital. For the study, 10 edentulous patients visiting the Department of Prosthodontics for complete denture prosthesis, were selected as subjects for this study. Following criteria of selection of the subjects were strictly adhered to: age group ranging between 40–70 years; healthy subjects from both genders with no systemic involvement especially respiratory diseases; residual alveolar ridge should be well formed/average; cooperative nature. A written informed consent was obtained from the participants after explaining them the protocol of the study. Results: Number of male patients was 6 and number of female patients was 4. The age of patients ranged between 40-70 years with mean age as 55.26 years. It was observed that all the spirometric values of the edenullus increased after receiving complete dentures. The results on comparing were found to be statistically non-signnificant. Conclusion: Within the limitations of the present study, it can be concluded that respiratory performance of edentulous patients improves with providing complete denture of appropriate vertical dimensions. Keywords: Complete denture, respiratory, spirometry.