Introduction- Acute pancreatitis is a mild self-limiting to severe life-threatening disease. Various scores and biomarkers predicting the outcome and severity of acute pancreatitis are available. Aim of study – To determine the role of biochemical markers like Procalcitonin (PCT) and Monocyte distribution width (MDW) in predicting severity of acute pancreatitis. Materials and methods – This prospective study was conducted on patients with Acute pancreatitis (Mild and Moderate- severe) admitted in the department of General surgery at DMCH, Ludhiana. Sample size was calculated as 120 patients. Clinical and laboratory data including values of PCT, MDW, CRP, serum amylase along with other parameters were recorded. Combined values of PCT and MDW were statistically analysed. Results- Out of 120 patients, 65 (54.2 %) patients had mild and 55(45.8%) had moderate-severe pancreatitis. Male predominance (74.2%) was seen with most common aetiologies being alcohol and gall stone. It was observed that combined values of PCT and MDW have better sensitivity than individual markers and better role in severity assessment. PCT and MDW combined have sensitivity of 70.91%, specificity of 55.38%, PPV of 57.35%, NPV of 69.23%. and accuracy of 62.50%. Conclusion- Early diagnosis plays an important role in its management. Inflammatory markers like PCT & MDW are easily available and can help in early prediction of severity and reduce the complications. Keywords – Acute pancreatitis (AP), Procalcitonin (PCT), Monocyte distribution width (MDW)