Background: This study was conducted to assess the efficacy of two different root canal sealers Material and methods: This study was conducted to assess the efficacy of two different root canal sealers. The subjects had been informed about the procedure and were asked for written informed consent for the study. The subjects who provided consent were included in the study while those who did not give consent had been excluded from the trial. There were total 100 subjects who gave consent for the study and hence they had been included. Two sealers had been used: MTA Fillapex and AH Plus. The subjects had been divided into 2 groups of 50 subjects each. The subjects of the first group were treated with MTA Fillapex while the subjects of the 2nd group had been treated with AH Plus sealer. The efficacy of these sealers had been assessed and the findings had been tabulated. Statistical analysis had been conducted using SPSS software. Results: In this study, there were 50 subjects in group 1 and 50 subjects in group 2. The teeth of the subjects of group 1 had been treated with MTA Fillapex sealer and the teeth of the subjects of the 2nd group had been managed with AH Plus sealer. The apical leakage in the MTA Fillapex group at 24 hours and after 180 days was 0.054±0.011 μL min-1 and 0.052±0.010 μL min-1, respectively. The apical leakage in the AH Plus group at 24 hours and after 180 days was 0.062±0.012 μL min-1 and 0.039±0.005 μL min-1, respectively. Conclusion: From the findings of this study, it can be declared that the AH Plus sealer was more effective as compared to MTA Fillapex root canal sealer. Keywords: Root canal, Sealers, Efficacy