Background: The study was conducted for the assessment of serum lipid profile in patients with oral precancer lesions. Material and methods: This study was conducted for the assessment of serum lipid profile in patients with oral precancer lesions. The study comprised of 135 participants who underwent oral clinical examination. The subjects had been asked for consent before proceeding with the study. The subjects who gave consent had been enrolled in the study. However, 35 out of 135 participants did not consent for the study and hence they were excluded from the trial. So finally, there were 100 participants who had been enrolled in the study and went oral clinical examination. The subjects had been divided into 2 groups of 50 each. Group 1 comprised of 50 controls and Group 2 comprised of 50 subjects with oral precancer lesions. The serum lipid profile of these 100 participants had been compared and the results had been tabulated. Statistical analysis was conducted using SPSS software. Results: In this study, there were 63 male and 37 female with oral precancer lesions. There were 50 subjects with oral precancer lesions in Group 2 and 50 controls in Group 1. The study's results indicated that individuals with a diagnosis of oral precancer exhibited an average plasma triglyceride concentration of 157.8 mg/dl, which is significantly lower than the control group's average of 117.9 mg/dl. Furthermore, the mean total cholesterol (TC) level in the precancer cohort was noted to be 154.2 mg/dl, in stark contrast to the non-cancer group, which presented a considerably higher mean of 213.7 mg/dl. The average levels of high-density lipoprotein (HDL) were recorded at 85.5 mg/dl for the non-cancer group, whereas the precancer group showed a markedly lower average of 34.1 mg/dl. Additionally, the mean plasma low-density lipoprotein (LDL) levels were 103.4 mg/dl in the non-cancer group compared to 56.2 mg/dl in the precancer group. The findings also revealed that the average plasma very low-density lipoprotein (VLDL) levels were 48.4 mg/dl in the control group, while the oral precancer group had an average of 8.57 mg/dl. Lastly, the ratio of total plasma cholesterol to HDL was determined to be 3.69 in the healthy cohort and 8.64 in the oral precancer group. Conclusion: The association between the risk of oral cancer and serum lipid profiles seems to exhibit a negative correlation. Studies suggest that a decrease in blood lipid levels may act as an early marker for neoplastic cellular changes before the onset of clinical symptoms. Keywords: precancer, serum lipid profile, triglycerides