Background: Recent decades have witnessed an escalation of global pandemics, each of which hampered business activities and economic growth. The present study was undertaken for comparing the online pharmacy shopping versus offline pharmacy shopping. Materials & methods: A total of 200 participants were enrolled. Innovative survey was carried out. Complete demographic and clinical details of all the participants were obtained. A survey based analysis was framed and self-framed questionnaire was given to all the subjects. Open questions were used, covering the topics of the study survey to map the general attitudes of the prospective sample. In the main study, data were collected directly from subjects using the outpatient health services for chronic or acute conditions. Results: 34.5 percent of the participants belonged to the age group of less than 30 years while 41 percent of the participants belonged to the age group of 30 to 50 years. 64 percent of the participants were males while the remaining were females. 84.5 percent of participants have head of online pharmacy shopping. 41 percent of the participants said they use online pharmacy shopping. 48 percent of the participants felt it unsafe to use online pharmacy shopping. Conclusion: Elderly age, female gender, rural residence and low literacy level were the factors responsible for non-use of online pharmacy shopping. Key words: Online, Pharmacy, Offline