Background: C-reactive protein (CRP), fibrinogen, and acute-phase proteins are sensitive markers to evaluate the inflammatory status. Periodontal therapy aims to alter or eliminate the origin of the microorganisms and also to prevent progression of the disease, thereby preserving the state of health of such individuals and avoiding recurrence of periodontitis. Periodontal pathogens affect the immune system and promote local and systemic inflammatory responses. Aim of the study: To assess C reactive proteins levels in patients with periodontitis. Materials and methods: The present study was conducted in the Department of Periodontology of the Dental institution. For the present study, we included a total of 100 patients with confirmed diagnosis of periodontitis. Another group of 100 patients with no systemic disease, those who were nonsmokers and those with acceptable oral hygiene, were also included in the study. An informed written consent was obtained from the participants. Gingival crevicular fluid was collected using a micro capillary pipette that was hand calibrated at every 1 mm till 10 mm, from selected sites in the subjects on 0 day, 14th day and 45th day. On every recall visit, i.e., 14th day and 45th day, oral hygiene instructions were reinforced and gingival crevicular fluid was collected for estimation of CRP. Results: In the present study, a total of 200 patients were included. 100 patients had periodontitis and 100 were healthy control subjects. The number of males in study group was 55 and in control group was 51. Number of female group was 45 and in female group was 49. We observed that the CRP level decreased significantly from baseline to 45th day in both groups. The CRP level was significantly higher in study group as compared to control group at baseline. Conclusion: Within the limitations of the present study, it can be concluded that CRP level was significantly higher in patients with periodontitis. The level decreased significantly with periodontal treatment. Keywords: Periodontitis, GCF, CRP, periodontal treatment