Presence of uric acid crystals in semen is not a uncommon finding. Several underlying causes have been explained over the years in the literature. Majority of the studied were focussed on the establishment of correlation in between these crystals and sperm parameters. Usually, these crystals are presented in semen asymptomatically however; rarely they can be painful when contaminated with superadded microbial colonies. Till date very few case reports have been presented by researchers worldwide. This paper is focussed on the Significance of presence of uric acid crystals in seminal fluid in a patient with history of infertility. Author has also reviewed several critical studies and their implications in these regards. Key words: Uric Acid Crystals, Infertility, Semen, Spermatozoa