Background: The relationship between diabetes mellitus & periodontitis has been extensively examined and it is clear from all the epidemiological studies that diabetes mellitus increases the risk for and severity of periodontal diseases showing a two way relationship between them. C-reactive protein (CRP) is a type I acute phase protein, which can increase up to 1000 fold after the onset of a stimulus. Thus the aim of this study was to estimate and compare the levels of Serum C-Reactive Protein & Interleukin-17 Levels in Chronic Periodontitis Patients with or without type 2 diabetes mellitus in systemically healthy participants with chronic periodontitis, participants with chronic periodontitis and type 2 diabetes mellitus. Materials & methods: A total of 50 subjects of both the sexes, in the age range of 18-65 years, were divided into following groups of 25 each on the basis of clinical and laboratory parameters as, Group 1: Chronic Periodontitis with Type 2 Diabetes Mellitus with RBS of ≥ 200 mg/dl and HbA1c of ≥ 7.5: Group 2 systemically healthy participants who have chronic periodontitis, defined as PPD of ≥ 5mm, CAL of ≥ 2mm and radiographic evidence of bone loss, Levels of Serum C-Reactive Protein & Interleukin-17 Levels was estimated using a commercially available ELISA kit. Results: Levels of Serum C-Reactive Protein & Salivary Interleukin-17 was highest in chronic Periodontitis and T2DM group. Periodontal clinical parameters PI, GI, PPD, CAL were recorded higher in chronic periodontitis and T2DM group when compared to when healthy participants who have chronic periodontitis. A statistically significant correlation between parameters such as FPG, HbA1c, PI, GI, PPD, CAL and salivary biomarkers were seen. Conclusion: The results showed an decrease in the levels of C-Reactive Protein & Salivary Interleukin-17 & HbA1c after periodontal therapy