Background: Acne vulgaris is one of the most common skin diseases with chronic inflammation of the pilosebaceous gland. The present study was conducted to assess self medication against Acne in medical students. Materials & Methods: 320 medical students having Acne were enrolled and information regarding the pattern of self-medication, knowledge about dose, reason for self medication, type of medication, mechanism of action, adverse effect, complication, precaution, and contraindication was obtained. Results: Out of 340 patients, males were 130 and females were 210. Reason for self medication was easy availability in 30%, lack of time in 25%, pharmacological knowledge in 40% and mildness of illness in 5%. The difference was significant (P< 0.05). Medications used were allopathic in 43%, Ayurvedic in 35%, homeopathic in 12% and cosmetic in 10%. The difference was significant (P< 0.05). Conclusion: Self medication for acne is common in medical students and use of allopathic Drugs. Awareness about the use of drugs, risk of adverse effects among medical students during their undergraduate medical training will help to reduce self-medication and subsequently it will also improve rational prescribing in their future career. Key words: Acne vulgaris, Allopathic, self-medication