Background: The present study compared effectiveness of two chlorhexidine mouth rinses on oral hygiene of patients wearing two different types of orthodontic brackets. Materials & Methods: The present study was conducted on 40 patients requiring fixed orthodontics. Patients were divided into 2 groups. Group I patients received metal-stainless steel brackets and group II patients received ceramic brackets. Both groups were subdivided into 2 subgroups. Subgroup I received a conventional, alcohol-free chlorhexidine solution (0.2% CHX) and subgroup II received a chlorhexidine solution with anti-discoloration system (0.2% CHX-ADS). Results: In group I, mean GI at baseline, 6 weeks and 16 weeks in subgroup I was 0.44, 0.32 and 0.36 respectively and in subgroup II was 0.42, 0.26 and 0.34 respectively. OHI in subgroup I, the value was 0.74, 0.52 and 0.66 and in subgroup II was 0.72, 0.46 and 0.52 at baseline, 6 weeks and 16 weeks respectively. The difference was non- significant (P> 0.05). In group II, mean GI at baseline, 6 weeks and 16 weeks in subgroup I was 0.37, 0.24 and 0.34 respectively and in subgroup II was 0.36, 0.10 and 0.34 respectively. OHI in subgroup I, the value was 0.67, 0.41 and 0.67 and in subgroup II was 0.62, 0.35 and 0.44 at baseline, 6 weeks and 16 weeks respectively. The difference was non- significant (P> 0.05). Conclusion: Authors found that ceramic brackets were better as compared to metallic brackets and CHX- ADS was more effective than CHX alone. Key words: Ceramic brackets, Metallic brackets, Chlorhexidine