Aim of the study: To compare two graft material Concept of GBR in infrabony defects. Materials and methods: The present study was conducted in the Department of Periodontology and implantology in Himachal Dental College Sunder agar, Himachal Pradesh . The subjects were patients who underwent simultaneous GBR using non-resorbable membranes and implant placement performed by the same department of Periodontology and implantology. A total of 10 patients were included in the study, 7 were males and 3 were females. The age of patients ranged from 32 years to 60 years, with mean age to be 46.39 years. Patients were divided into two groups according to the type of membrane used i.e. e-PTFE or d-PTFE. The patients were assigned randomly to either the e-PTFE group or the d-PTFE group according to the order of the surgery. The effect of each barrier membrane was assessed by measuring the amount of the bone defect at the time of the GBR and second surgery after GBR. Results: vertical bone defect around implant fixture at the time of the first surgery are shown in Table 2 (P>0.05). With regard to the amount of the bone defect, a statistically significant difference between the two groups was not detected. The marginal bone loss after functional loading was compared, and a significant difference between the two groups was not observed. Conclusion: Within the limitations of the present study, it can be concluded that e-PTFE and d-PTFE did not show a significant difference in bone regeneration effects. Keywords: Guided bone regeneration, infrabony defects, GBR.