Background: Patients with periodontal disease have higher concentrations of circulating inflammatory markers, including C-reactive protein (CRP) and cytokines. Hence; the present study was conducted for assessing C Reactive proteins levels in chronic periodontitis patients. Materials & methods: A total of 15 patients with clinical and radiographic confirmed diagnosis of chronic periodontitis and 15 healthy controls were enrolled. Demographic characteristics, such as age, gender, diet, and medical history, body mass index were recorded. A set of full-mouth periapical radiographs was taken. Fasting (minimum of 12hrs) venous blood samples were collected. The venous blood was collected in plain vials which were sent to the laboratory for biochemical analysis and evaluation of systemic parameters of both case group and control group. Serum Highly sensitive C- reactive protein levels were assessed by means of latex enhanced auto-analysing method. Results: Mean C reactive proteins levels of the patients of the chronic periodontitis group and the control group was found to be 0.715 mg/dL and 0.278 mg/dL respectively. Significant results were obtained while comparing the mean C Reactive proteins levels among the patients of the chronic periodontitis group and the control group. Conclusion: Increase in periodontal inflammation is accompanied by a substantial increase in the concentration of C Reactive proteins levels. Key words: C Reactive proteins, Periodontitis