Collagen is the largest and most abundant protein in the body, making up about 65% of our total protein. It is a fibrous protein, found mainly in the skin, bones, muscles, cartilage, tendons, ligaments where it forms a scaffold to provide strength and structure. As collagen forms building block of body structures, any defect in collagen results in disorders. This review highlights the role of collagen in disorders associated with structural and functional defects in collagen. Keywords: Collagen, Extracellular matrix, Genetics, Disorders