Background: Articaine is an amide local anesthetic that differs from other agents of its group due to the presence of a thiophene ring instead of a benzene ring, and it is one of the commonly used local anesthetic agents for day care surgeries. Some researches claim that articaine is superior to lidocaine in its biologic profile. Material and method: 90 patients were included in this study who were supposed to undergo orthodontic extraction of maxillary premolar teeth. 0.5 ml of 4% articaine HCl with 1:100,000 adrenaline solution was used for buccal infiltration for anesthetizing maxillary teeth. Similarly, 0.6 ml and 0.3mi of 2% lignocaine HCl with 1:80000 adrenaline solution was used for buccal and palatal infiltration respectively for anesthetizing maxillary teeth on the other side. VAS (visual analog scale) was used to evaluate pain during extraction. SPSS software was used for statistical analysis. Results: 41 out of 90 patients were males comprising of 45.55% of the study sample. 74.44% of the sample size was below 16 years of age. Volume of solution of lignocaine group was higher than that of articaine group. Only 0.5 ml of articaine was used for buccal infiltration. The mean time of onset of anesthesia came out to be 37.38 ± 26.41seconds and 81.56 ± 28.94 s in articaine group and lignocaine group respectively. Conclusion: Atricaine showed a faster onset and longer duration of action of anesthesia as compared with lignocaine HCL. Moreover a lesser volume of articaine was sufficient to induce profound anesthesia and thus, articaine can be used as an alternative to lignocaine as a local anesthetic agent in dental procedures. Key words: Local anaesthesia, Extraction, Articaine.