Background: Periodontitis is a chronic inflammatory disease caused by bacterial infection of the supporting tissues around the teeth. Serum albumin levels might be the practical marker of general health status. Albumin concentration is associated with nutrition and inflammation. Material and method: 200 patients were enrolled in this study. These patients were divided into two groups of 100 each: Group 1: 100 patients with clinical and radiographic diagnosis of chronic periodontitis, Group 2: 100 clinically healthy. All demographic details, clinical and radiographic data of these patients was obtained. Fasting blood samples of the patients were collected. These samples were sent to laboratory for biochemical analysis of serum albumin levels. An autoanalyser was used to calculate the levels of serum albumin. Results: Out of 200 patients 66 patients were less than 35 years old and 134 patients were above 35 years of age. Out of the 100 patients in the periodontitis group 71 patients were above 35 years of age and only 29 were below 35 years of age. 61 out of 100 patients in the periodontitis group being males. The rural population was more affected with periodontitis. Mean serum albumin levels among the patients of the periodontitis group were found to be 4.37 g/dL. Mean serum albumin levels among the subjects of the control group were found to be 5.01 g/dL. Mean serum albumin levels among the patients with chronic periodontitis group was significantly lower in comparison to the control group. Conclusion: Reduced serum albumin concentration was observed in patients suffering from chronic periodontitis.