Background: Periodontal disease is a chronic inflammatory disease of periodontium and its advanced form is characterized by periodontal ligament loss and destruction of surrounding alveolar bone. IL-6 is known to increase the hepatic expression of CRP (C reactive proteins), which is now considered to have direct effects on the vascular wall, contributing to atherogenesis. Hence; the present study was undertaken for assessing the salivary Levels of IL-6 levels in chronic periodontitis patients. Materials & methods: A total of 50 patients with chronic periodontitis and 50 healthy controls were enrolled in the present study. Radiographic data of all the patients was obtained and was analysed. Patients with history of any other systemic illness or any presence of any metabolic disorder were excluded from the present study. All the patients were called in the morning and Unstimulated salivary samples were obtained in a test tube. The samples were sent to central laboratory where auto-analyser and ELISA technique was used for evaluation of salivary IL-6 levels. Results: Mean salivary IL-6 levels among the patients of the periodontitis group and the control group was 69.75 ng/L and 14.28 ng/L respectively. While analyzing statistically, it was observed that mean IL-6 levels of the saliva among the periodontitis patients was significantly higher in comparison to the healthy controls. Conclusion: Chronic periodontitis patients are associated with significantly higher salivary levels of IL-6, highlighting their role in pathogenesis of the disease. Key words: IL-6, Periodontitis, Salivary.