Background: Periodontal disease is an inflammatory process that affects the protective and supportive tissues around the tooth. C- Reactive Proteins (CRP) is a pentameric plasma protein with homologs in vertebrates and many invertebrates that participate in the systemic response to inflammation. Hence, we planned the present study to assess the effect of non-surgical periodontal treatment on circulating serum high sensitivity capsule reactive protein (C Reactive proteins) levels in chronic periodontitis patients. Materials & methods: A total of 20 patients with confirmed diagnosis of chronic periodontitis were enrolled. A set of full-mouth periapical radiographs was taken. The oral hygiene and gingival status was assessed. All measurements were made by a single trained examiner. All the patients underwent instruction on oral hygiene techniques, demonstration of a manual tooth brushing, interproximal brushing, the use of dental floss, as well as supragingival prophylaxis. Fasting (minimum of 12hrs) venous blood samples were collected prior to any manipulation at baseline and six months after the treatment. Serum Highly sensitive C- reactive protein levels were assessed by means of latex enhanced nephlelometric method. All the results were analysed by SPSS software. Results: Mean C reactive proteins levels during pre-treatment phase were found to be 2.8 mg/dL. Mean C reactive proteins levels 6 months post-treatment were found to be 1.7 mg/dL. While analysing statistically, mean C reactive protein levels were significantly reduced 6 months post-treatment following non-surgical periodontal therapy in chronic periodontitis patients. Conclusion: Serum C reactive levels are significantly reduced following non-surgical periodontal therapy. Key words: Periodontal therapy, C reactive proteins