Backgrounds: The success and predictability of implants are well established. Cigarette smoking is still considered a common habit. Hence; the present study was undertaken for assessing the correlation between smoking and dental implant prognosis. Materials & methods: A total of 50 smokers and 50 non-smokers were enrolled in the present study. Only those patients were included in the smoker group and non-smoker group who underwent dental implant therapy for missing maxillary first molar. Only those patients were included under the smoker group who had positive smoking history of more than 10 cigarettes per day for a minimum of 5 years. Complete demographic details of all the patients were obtained. All the dental implant procedure was carried out under the hands of skilled and experienced Prosthodontist. Follow-up was done and clinical and radiographic evaluation of all the patients was done at follow-up. Results: Among the smokers group, dental implants were successful in 76 percent of the patients while in the remaining 24 percent of the patients, failure of dental implants occurred. In the non-smoker group, dental implants were successful in 96 percent of the patients while in the remaining 4 percent of the patients, failure of dental implants occurred. While comparing the success of dental implants in between smokers and non-smokers, non-significant results were obtained. Conclusion: In smokers, dental implants do not have good prognosis in comparison to non-smokers. Key words: Dental implants, Smoking