Oral Cancer is the 11th most common malignant disease in the world. Late diagnosis, high mortality rates and morbidity are characteristics of the disease. The estimated incidence, mortality and 5-year survival due to lip, oral cavity cancer in the world is 2.1%, 1.8% and 2.2% respectively according to data of GLOBOCAN 2012. This review summarizes the incidence, prevalence and mortality rates associated with oral cancer in different regions of the world. Key words: Oral Cancer, Tobacco Chewing, alcohol consumption, trends in oral cancer, oral cancer epidemiology.