Background: Acute infectious encephalitis/encephalopathy syndrome (AIES) is characterized by fever with impaired consciousness ranging from confusion to coma. The present study assessed the outcome of acute infectious encephalitis. Materials & Methods: The present study was conducted on 86 patients of AIES of both genders. In patients features like presence of fever, headache, vomiting, altered sensorium, bleeding diathesis and respiratory symptoms were noted. Blood pressure, pulse rate, jaundice, edema, lymphadenopathy, flushing, skin rash and bleeding diathesis were also recorded. Results: Out of 86 patients, males were 42 and females were 46. Clinical features were hypotonia in 45, seizures in 32, areflexia in 13, focal weakness in 18, hypotension in 57, pneumonia in 23, bleeding in 17, muscle dysfunction in 44 and raised ICP in 67. The difference was significant (P< 0.05). The mean SOPA score was 12.4, GCS score was 7.3, hemoglobin was 10.56 gm/dl and leukocyte count was 15.2 mm.362 patients survived and 24 died. Conclusion: Authors found that common features were hypotonia, seizures, areflexia, focal weakness, hypotension, pneumonia, bleeding, muscle dysfunction and raised ICP. Key words: Hypotonia, Seizures, Encephalitis