Spindle cell carcinoma is an aggressive variant of squamous cell carcinoma which recurs frequently and metastasize. It is a rare biphasic tumor consisting of squamous carcinoma associated with a malignant spindle stromal compound, but of an epithelial origin. Selective sampling of this specimen for possible transitional areas of squamous and spindle cell appearance are helpful in establishing the diagnosis. We report the occurrence of this neoplasm in the lower left retromolar region as an ulceroproliferative lesion in a 62-year-old male patient.
Keywords: Spindle cell carcinoma, biphasic tumor, sarcomatoid carcinoma.

Corresponding author: Dr. Imran Mohtesham, Department of Oral Pathology and Microbiology, Yenepoya Dental College, Yenepoya University, Nithyananda Nagar, Mangalore-575018, Karnataka, India, E mail:  himohtesham@yahoo.com
This article may be cited as: Mohtesham I, Nishana M, Abdulla R, Prabhu V. Spindle cell differentiation in oral squamous cell carcinoma- A rare entity. Int J Res Health Allied Sci 2016;2(4):26-28.