Introduction: - Life style and diet play an important role in the pathogenesis of oral cancer. Unfortunately, under the present day life style conditions, many people run an abnormally high level of oxidative stress that could increase their probability of early incidence of decline in optimum body functions and lead to a number of pathologies. Hence this study aimed to estimate serum and salivary albumin and uric acid levels in healthy individuals, oral sub mucous fibrosis and oral squamous cell carcinoma patients.
Methodology: - Study comprised of three groups as follows: Group I: Comprised of 10 healthy individuals. Group II: 20 otherwise healthy and consenting patients with Oral Submucous Fibrosis, Group III: 20 otherwise healthy and consenting Oral Squamous Cell Carcinoma patients. Venous blood was drawn and Unstimulated whole saliva was collected after the clinical diagnosis followed by biochemical estimation of serum and salivary albumin and uric acid with the help of Semiautomatic Analyzer. The results were analyzed using students -t test and were averaged as mean ± standard deviation with p- value < 0.05 considered to be statistically significant. The normality of data was checked before the statistical analysis was performed. Results - Inter comparison of serum albumin and uric acid  levels between all the three groups revealed that the difference was statistically significant, indicating that serum albumin and uric acid levels decreased in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma compared to healthy individuals. Salivary albumin levels significantly increased in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma cases compared to healthy individuals. Whereas salivary uric acid levels significantly decreased in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma cases compared to healthy individuals.  Conclusion - The results obtained emphasize the need for more studies with larger sample size to be conducted before a conclusive role could be drawn in favor of serum and salivary albumin and uric acid as diagnostic markers of significance in oral sub mucous fibrosis & Oral Squamous Cell Carcinoma.
Key words: Saliva, Albumin, Uric Acid, free radicals, Oral Sub Mucous Fibrosis ,Oral Squamous Cell Carcinoma.

Received: 12 November 2018                              Revised: 8 December 2018                           Accepted: 10 December 2018

Corresponding author: Dr. Nidhi Khajuria, M.D.S Oral Pathology, Registrar, Department of Oral Pathology, IGGDC, Jammu, J & K, India,

This article may be cited as: Tiwari P, Khajuria N, Metgud R. Estimation of Serum and Salivary Albumin and Uric Acid Levels in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma: A Biochemical Study. Int J Res Health Allied Sci 2019; 5(1):5-9.