Introduction:  Surgical endodontics is a reliable method for the treatment of teeth with periapical lesions that do not respond to conventional root canal treatment. A more recent paradigm shift from classical endodontic surgery to regenerative endodontic therapy is further revolutionized by the introduction of Platelet rich fibrin. Aim: Endodontic management of periapical lesion using MTA and platelet – rich fibrin membrane as regenerative procedure. Method: A 25 year old male patient complaint of pus discharge from his upper front teeth. Large periapical lesion and perfortion was seen on intraoral periapical radiograph. The treatment plan executed was root canal therapy followed by endodontic surgery using PRF and retrograde MTA irt 11, 12.  Results: At the end of six months, patient showed considerable bone regeneration. Conclusion: Production of a dense, cross-linked, physically robust PRF made of intact platelets and fibrin by high speed centrifugation, yields an ideal scaffold for use in tissue repair.
Keywords: PRF, periapical lesion, endodontic surgery, retrograde MTA.

Corresponding Author: Dr. Dr Neetu Bala, Add: 199/8, Panchkula, Haryana, India

This article may be cited as: Bala N, Bhullar KK, Sapra M. Surgical Management of Large Periapical Lesion Using PRF and MTA: A Case Report. Int J Res Health Allied Sci 2016;2(4):86-88.