One of the most plastic cells of the hematopoietic system that are located in almost all tissues is the macrophages. They exhibit a great deal of functional diversity. Apart of having distinctive roles in development, homeostasis, tissue repair, and immunity, they can be can be subverted by chronic insults, resulting in a causal association of macrophages with disease states. In this review, we highlight the pathophysiological role of macrophages in the normal development process and various pathologic conditions including pre-malignancies and malignant neoplasm. This pathogenesis can help in throwing light on the use of these macrophages as therapeutic targets for treatment.
Key words: Carcinoma, Lichen planus, Macrophages

Corresponding author: Dr. Deepak Narang, Senior Lecturer, Oral Medicine & Radiology, Azamgarh Dental College, Itaura, Azamgarh, Uttar Pradesh, E mail: parasitology1979@gmail.com

This article may be cited as: Narang D, Rathod V, Khan F, Sur J, Kulkar V, Pandey A, Kulshreshtra R, Desai V. Macrophages in health and diseases: a systemic review. Int J Res Health Allied Sci 2016;2(2):22-31.