Aim: To evaluate the CRP levels in peri-implantitis patients. Materials and methods: This study examines the effects of dental implants on systemically healthy adult patients aged 20–75 years who required implants in either jaw. A total of 30 patients were enrolled based on specific inclusion criteria, including voluntary participation and the absence of underlying medical conditions or medication use. Data analysis was done using SSPS software. Results: The patients' ages ranged from 20 to 75 years, with a mean age of 36.1 ± 15.37 years. Pre-treatment CPSS values varied between 39 and 163, with a mean of 89.13 ± 32.24, while post-treatment CPSS showed a reduction, ranging from 14 to 151, with a mean of 45.03 ± 55.02. Similarly, pre-treatment hs-CRP levels ranged from 0.71 to 5.11 mg/L, averaging 3.12 ± 2.17 mg/L, whereas post-treatment values ranged from 0.04 to 5.63 mg/L, with a mean of 2.01 ± 0.63 mg/L. Conclusion: The study showed a decrease in the number of participants with elevated hs-CRP levels after scaling and root planing (SRP), while the number of participants with lower hs-CRP levels increased. This suggests that SRP contributed to a reduction in systemic inflammation.