Cancer that develops between the red line on the lips and the point where the hard and soft palate meet, or the back part of the tongue, is referred to as oral cancer. More than 95% of patients with oral squamous cell carcinoma (OSCC) either use alcohol or use tobacco-based products, or areca net. Early detection through screening is an appropriate intervention to prevent this deadly disease because treatable lesions are rarely symptomatic. Radiotherapy, surgery, chemotherapy or combination any of these three can be used as a form of treatment; however, surgery is typically proven to be the most effective aid in treating cancers of the oral and maxillofacial complex. This case report focuses on a 67-year-old male patient diagnosed with carcinoma of the right buccal mucosa, emphasizing the importance of early detection and a multidisciplinary treatment approach. KEYWORDS: Oral Squamous cell carcinoma, radiotherapy, mandible, case report, neck dissection.