INTRODUCTION: Acute pancreatitis is inflammation of pancreas that can be associated with peri-pancreatic collection and sepsis. Aim of Study: 1) To study the clinical profile in acute pancreatitis patients, 2) To study the peri-pancreatic collection/necrosis and the outcome in terms of any intervention: MATERIALS & METHODS: A prospective study was conducted in 100 patients with acute pancreatitis admitted at DMCH, Ludhiana. RESULTS: Maximum cases were in age group of 31-40 (27%) with male predominance (67%) with biliary etiology (44%). Radiological evidence was seen in 90% cases with peripancreatic collection in 53%. NJFT was put in 66% cases. 58 patients were admitted in ICU with ventilator support (25%) and inotropes (31%) cases. PCD insertion was done in 34 patients and necrosectomy in 11, ERCP in 5 patients and cholecystectomy in 3 cases. In 44 Peripancreatic Collection Samples, 40 showed growth (positivity rate 90.9%) with Klebsiella – most common isolate. Mean length of stay in the hospital was 19 days. Final outcome of patients included 65% discharged, 24% took DAMA and 5% expired. CONCLUSION: This study helped us to find out that how severity of acute pancreatitis and the interventions are related and its impact on the final outcome of the patients. Patients with positive cultures were in need of NJFT, ICU care, ventilator support and inotropes and were not only managed medically but also with interventions including ERCP, PCD insertion and surgeries with length of hospital stay increased. KEYWORDS: Prospective Study, Acute Pancreatitis, Clinical Profile, Outcomes