Aim: to assess serum metal ion levels in patients with dental implants. Materials and methods: The study included 50 patients aged 18 to 50 years who required dental implants in either jaw. Eligibility criteria included patients with missing teeth aged 18 to 50 years, while those with underlying medical conditions, corticosteroid or other medication use, or a history of orthopedic or dental implants were excluded. Demographic data, including age and gender, were recorded. A comprehensive oral examination was conducted, followed by CBCT imaging to assess bone quality, anatomical structures, and any pathologies. A 5 ml venous blood sample was collected to measure titanium and aluminium ion levels. All patients underwent implant placement and were followed up at 4 weeks, 6 months, and 1 year for ion level assessment. Statistical analysis was performed, using SSPS software. Results: Out of 50 patients, 30 (60%) were male, and 20 (40%) were female. Preoperatively, the mean titanium ion level was 1.67 mg/dL (SD: 0.11) with a p-value of 0.20. At 4 weeks postoperatively, the mean level declined to 1.52 mg/dL (SD: 0.16), followed by a further reduction at 6 months to 1.40 mg/dL (SD: 0.14). By the 1-year follow-up, the titanium ion level had decreased to 1.29 mg/dL (SD: 0.19). Similarly, the mean aluminium ion level preoperatively was 3.91 mg/dL (SD: 0.11) with a p-value of 0.27. At 4 weeks postoperatively, it decreased to 3.62 mg/dL (SD: 0.17), followed by a further reduction at 6 months to 3.49 mg/dL (SD: 0.12). However, by the 1-year follow-up, a slight increase was noted, with the mean aluminium ion level rising to 3.64 mg/dL (SD: 0.21). Conclusion: Patients who received dental implants showed no significant changes in blood titanium and aluminium ion levels.