Background: Endodontic therapy, also known as root canal therapy, is a series of treatments aimed at addressing the infected pulp of a tooth. The goal is to eliminate the infection and safeguard the thoroughly cleaned tooth from potential microbial invasions in the future. The objective of the current study was to evaluate the factors contributing to failures in endodontic procedures.Methods:The research was conducted by involving 156 patients of diverse genders. The study encompassed a total of 280 teeth that had undergone endodontic treatment. Evaluation focused on various factors, such as missed canals, dislodged or fractured restorations, and iatrogenic issues, including perforations, file separations, and ledges.Results:A prevalent cause of endodontic failure was identified, with inadequate obturation accounting for 45%, missed canals for 20%, and fractured coronal restorations for 35%. The observed differences were found to be statistically significant (P<0.05).Conclusion:Endodontic failure can stem from a variety of reasons, with the most frequent culprits being a missed canal, inadequate obturation, and fractured coronal obturation.