Background: The present study was conducted for evaluating renal profile in liver cirrhosis patients.Materials & methods:100 patients with presence of cirrhosis of liver were enrolled. Complete demographic and clinical details of all the patients was obtained. Patients with presence of any pre-existing co-morbid condition or pathology were excluded from the present study. Clinical examination of all the patients was carried out. Complete medical examination was done of all the patients. This was followed by grading according to Child-Pugh score. All the patients were recalled in the morning and blood samples were obtained. All the samples were sent to laboratory where renal and biochemical profile was evaluated. Results: Deranged renal profile was seen in 30 percent of the patients. Mean blood urea and serum creatinine levels were found to be 37.6 mg/dL and 1.29 mg/dL respectively. Mean serum bilirubin level were found to be 2.45 mg/dL. Out of 30 patients of class A of Child Pugh score, 13.33 percent had deranged renal profile while 28.89 percent of the patients of class B of Child Pugh score had deranged renal profile. 52 percent of the patients of class C of Child Pugh score had deranged renal profile. Significant results were obtained while correlating serum renal profile with severity of cirrhosis of liver.Conclusion: Significant association was observed between severity of liver dysfunction and renal dysfunction. Hence; we should be more vigilant when treating patients with cirrhosis of liver, regarding their renal function, as adequate screening can decrease associated morbidity and mortality.