Background: This study was conducted to assess the effect on micro tensile bond strength of self-etch adhesive on dentine irrigated using different irrigants. Material and methods: This study utilized a collective of 30 molars. The study excluded teeth that exhibited hypo-plasticity, hypo-mineralization, restorations, and crown fractures. A total of 30 undamaged human molars were utilized and categorized into 3 groups based on the irrigants used. A self-etch universal adhesive method was employed for the composite restoration. The construction of resin composites was achieved by utilizing the Tetric N Bond Universal adhesive method. The microtensile bond strength was assessed using a Universal Testing Machine. The collected data was organized and inputted into a spreadsheet using Microsoft Excel. It was subsequently exported to the data editor of SPSS Version 20.0. The statistical analysis of the data was conducted using the software SPSS (version 20.0) and Microsoft Excel. Results: The mean bond strength of group 1 adhesives was 21.3 while the mean bond strengths of group 2 and 3 were 27.9 and 30.5, respectively. Conclusion: the control group showed the least bond strength as compared to the other 2 groups.