Introduction- This cross-sectional study delves into the investigation of serum uric acid levels among individuals diagnosed with oral squamous cell carcinoma (OSCC). The research aims to shed light on the potential correlation between serum uric acid levels and the occurrence of OSCC. By employing a cross-sectional design, we aim to analyze and interpret the data to contribute valuable insights into the understanding of OSCC and its potential biochemical associations. Materials and methods- The study involved the recruitment of 70 subjects, with the study group consisting of patients clinically diagnosed with oral squamous cell carcinoma (OSCC) (n=45), alongside 25 individuals serving as healthy controls. Results-Oral squamous cell carcinoma (OSCC) exhibited a predominant diagnosis in males, comprising 53% of the cases. The occurrence of oral lesions was notably associated with tobacco habits and the chewing of betel quid/areca nut. Conclusion- The serum uric acid levels displayed a reduction in oral squamous cell carcinoma (OSCC) patients, when compared to healthy controls. Keywords: Carcinoma, Uric acid, Alcohol