Background: The present study was conducted for analyzing the effectiveness dexmedetomidine to attenuate the blood pressure response to tracheal extubation. Materials & methods: A total of 20 patients were enrolled. Only those patients were included which were scheduled to undergo general surgical procedures in general anaesthesia. Group A received Dexmedetomidine and Group B received I.V. infusion of Normal Saline. Mean arterial pressure, systolic blood pressure and diastolic blood pressure was assessed at different time intervals. All the results were recorded and analyzed using SPSS software. Results: Majority proportion of patients of both the study groups were males. Systolic blood pressure, diastolic blood pressure and mean arterial pressure was significantly higher among patients of group B in comparison to group A at all time intervals except for baseline. However; while making intra-group comparison, non-significant results were obtained at 30 mins after extubation while comparing mean arterial pressure and DBP. Conclusion: Intravenous dexmedetomidine before extubation significantly attenuates the blood pressure responses to extubation. Key words: Dexmedetomidine, Extubation