Background: In the head and neck, oral cancer is the most common malignant tumour, with more than 300,000 new cases and 145,000 fatalities each year worldwide. In order to determine if the trace elements had any part in the aetiology of cancer, they were thoroughly examined in recent years. Therefore, in consideration of the aforementioned information, the current study was conducted to measure the copper and zinc levels in patients with oral cancer who had saliva. Materials & methods: A total of 50 patients with oral cancer and 50 healthy controls were included in the study. Only individuals whose diagnosis of oral cancer was verified by a histological examination were included in the study. Salivary samples were taken from each patient who was summoned back in the morning. All samples were delivered to the lab, where the copper and zinc levels in the saliva were measured using an auto-analyser. SPSS software was used to record and interpret each outcome. Results: A total of 50 oral cancer patients and 50 healthy controls were included in the study. Patients in the oral cancer group and the control group had median ages of 44.2 and 47.9 years, respectively. The remaining patients were female, with 32 in the control group and 36 in the oral cancer group being men. Patients in the oral cancer group and the control group had mean salivary copper concentrations of 19.78 ppb and 83.67 ppb, respectively. Patients with oral cancer and controls had median salivary zinc levels of 131.56 ppb and 164.24 ppb, respectively. It was discovered through statistical comparison that the mean salivary zinc and copper levels among patients with oral cancer were considerably lower than those of the healthy controls. Conclusion: Copper and zinc are involved in the pathogenesis of head and neck malignancies. Key words: Oral cancer, Salivary, Copper, Zinc