Background: Glass-ionomer cements belong to the class of materials known as acid-base cements. In the recent past, a variety of newer types of GICs such as light cured GIC, resin modified GIC (RMGIC), compomer, and nanofilled GIC has been introduced in the field of dentistry.9 Hence; we planned the present study to assess the micro-leakage in between conventional and compomer cements in deciduous teeth. Materials & methods: The present study included assessment of micro-leakage in conventional and modified glass ionomer cement in deciduous teeth. A total of fifty non-carious freshly extracted deciduous molars were included in the present study. Group A consisted of specimens in which GC Fuji II was used while group B included specimens in which Compoglass was used. Preparation of standard class V cavity was done on the buccal surfaces of all tooth specimens. All the teeth were immersed in 0.5% methylene blue dye for 24 h. Sectioning of the tooth was done followed by scoring using criteria given previously in the literature, from score zero to score four. All the results were compiled and analysed by SPSS software. Results: Among group A specimens, 12 and 13 specimens showed micro-leakage score zero and one respectively. Among group B specimens, 11, 8 and 6 specimens showed micro-leakage score of 11, 8 and 6 respectively. We observed non- significant result on comparing the mean micro-leakage score in both the study groups. Conclusion: Approximately equal amount of micro-leakage is exhibited by both the types of GIC used in the present study. Key words: Deciduous, Glass ionomer cement, Micro-leakage Corresponding Author: Dr. Pooja Pani, PG Student, Department of Pedodontics and Preventive dentistry, Awadh Dental College and Hospital, Jharkhand This article may be cited as: Pani P, Nishant, Rajguru JP, Somayaji NS. In-vitro assessment of micro-leakage in conventional and modified glass ionomer cement in deciduous teeth: A comparative study. Int J Res Health Allied Sci 2017;3(4):78-80.