Background: To evaluate C- reactive protein levels in periodontitis. Materials & methods: A total of 40 systemically healthy subjects were divided into two groups: Group I, nonperiodontitis subjects and group II, chronic generalized periodontitis patients. Gingival index was calculated. The results were analysed using SPSS software. The p – value less than 0.05 was considered significant. Results: The mean CRP (mg/L) levels for both groups were 0.99 and 2.40, respectively. CRP values of the two groups were significantly different from each other, with CRP levels in the group II greater than those in the group I subjects. Conclusion: Increase in serum CRP levels in subjects with generalized periodontitis Keywords: CRP, Plaque index, Periodontitis.