Oral cavity works as an early indicator for variety of underlying systemic diseases. Thorough dental examination of the oral mucosa, teeth, gingiva and all other hard and soft tissues of the oral cavity by the periodontist leads to early, accurate and timely diagnosis of these underlying systemic diseases. Although, gingival enlargement may occur due to local factors like plaque in oral cavity, this gingival enlargement as oral manifestation also expressed as in systemic conditions such as endocrinal imbalance, blood dyscrasias, hereditary and cancerous conditions. Acute myeloid leukemia (AML) is a malignancy of bone marrow, a cancerous disease that may lead to significant fatality rate if not diagnosed timely. A 36 years old female reported with chief complaint of generalized gingival enlargement associated with spontaneous bleeding and ulceration of the gingiva. So, the aim of this case report was to report the generalized gingival enlargement in an rare case of AML patient, emphasizes the importance of proper and thorough examination of oral cavity, proper dental management, health education, motivation and timely referral of the patient to the oncology department for further needful treatment to avoid the dreadful condition. Keywords: Acute myeloid leukemia, bone marrow, generalized gingival enlargement, systemic disease.