Background: Multiple extraoral and intraoral forces and factors could impact their inclination and position of incisors. The aim of the present study was to compare the maxillary and mandibular incisors inclination in hyperdivergent and hypodivergent patients. Materials and methods: The study included pre-treatment lateral cephalograms of 90 patients (45 hyperdivergent, 45 hypodivergent) having skeletal class I with cervical vertebrae maturation stage 5 or 6. Mean age of the sample (60 females, 30 males) was 20 ± 3 years. Facial divergence was determined by mandibular plane angle (SN-MP). Hyperdivergent patients had SN-MP > 36˚, whereas hypodivergent patients had SN-MP < 28˚. Maxillary incisor inclination was determined by Upper incisor – palatal plane angle (U1-PP) and mandibular incisor inclination was determined by incisor mandibular plane angle (IMPA). Results: In hyperdivergent group, mean inclination of maxillary incisor was 119.82˚ ± 7.35˚ whereas in hypodivergent group, it was 114.20˚ ± 3.4˚. Statistically significant difference was present in both maxillary incisor inclination (P= 0.000011) and mandibular incisor inclination (P= 0.000737) between hyperdivergent and hypodivergent groups. Conclusion: It is concluded that vertical facial pattern has a significant impact on incisors inclination. Both maxillary and mandibular incisor inclination were greater in hyperdivergent patients as compared to hypodivergent patients. Keywords: Incisor inclination, Hyperdivergent, Hypodivergent, Mandibular incisor, Maxillary incisor