One of the commonest ailments prevalent among these population groups is partial or complete edentulousness. Hence the dentist /speciality dentist plays a significant role in executing the rehabilitation procedure. Esthetic considerations aside, the layer of plaque which forms on the tissue-fitting surface of the denture is probably of greatest clinical significance. A variety of soft tissue changes are associated with complete or removable partial dentures. Hence; the present review was undertaken for summarizing antimicrobial efficacy of commercially available of denture cleansers on heat polymerized acrylic resins. Key words: Denture, cleansers