Background: Patients with Parkinson’s disease (PD) and dysautonomia often present elevated blood pressure (BP) variability. The present study was conducted to assess correlation between left ventricular function indices and blood pressure variability in patients with Parkinson’s disease. Materials & Methods: 16 Parkinson’s disease with dysautonomia patients of both genders were put in group I and group II patients had grade I-II uncomplicated hypertension. Measurement of chambers, wall thickness and LV mass was performed. LV ejection fraction was measured with the Simpson’s method. BP variability was evaluated through average real variability. Results: End systolic value was 27.3 and 27.8, end diastolic was 63.1 and 64.7, LV mass, index was 126.5 g/m2 and 130.7 g/m2, LVEF was 62.1% and 61.5% and LA volume indexed was 50.1 ml/ m2 and 52.4 ml/ m2. GLS was 19.2 and 20.4, GCS was 23.6 and 23.9 and GRS was 22.4 and 21.9 in group I and II respectively (P< 0.05). The mean 24/h systolic BP was 121.4 and 135.2, diurnal systolic BP was 121.4 and 136.5, nocturnal systolic BP was 120.4 and 125.8, 24/h diastolic BP was 74.2 and 82.3, diurnal diastolic BP was 75.6 and 87.4 and nocturnal diastolic BP was 74.3 and 77.6. 24/h systolic BPV was 8.4 and 6.5, diurnal systolic BPV was 8.5 and 7.0, nocturnal systolic BPV was 10.2 and 6.5, 24/h diastolic BPV was 3.7 and 3.2, diurnal diastolic BPV was 3.6 and 3.2 and nocturnal diastolic BPV was 3.1 and 3.0. The difference was significant (P< 0.05). Conclusion: An inverse significant correlation existed between GLS and 24/h systolic BP variability in patients with PD. Key words: Blood pressure, Dysautonomia, Parkinson’s disease