Background: We planned the present study to assess to salivary nickel levels in patients undergoing fixed orthodontic treatment. Materials & methods: A total of 40 subjects undergoing fixed orthodontic treatment were enrolled in the present study. A total of 40 age and gender matched healthy controls were also included in the present study. All the subjects were called in the morning and fasting salivary samples were collected in cold polypropylene tube. Before sample collection, subjects were instructed to rinse their oral cavity from 25 to 30 seconds. All the samples were sent to laboratory for further assessment. In the laboratory, the assessment of salivary nickel levels was done using atomic absorption spectrophotometer.. Results: Mean salivary nickel levels among the patients of the study group were 20.6 ng/ml and were significantly higher in comparison to the mean salivary nickel levels among the patients of the control group (13.9 ng/ml). Conclusion: Corrosion of fixed orthodontic appliances leads to elevated salivary nickel levels early after the initiation of orthodontic treatment. Key words: Salivary, Nickel