Volume 6 Issue 6 (November - December), 2020

Original Articles

Assessment of the renal functions in patients with chronic liver diseases
Pranav Patwardhan, Varsha Bhatt, A.L.Kakrani, Manaswini Edara, Kanitkar S

Background: The present study was undertaken for assessing the renal functions in patients with chronic liver diseases. Materials & methods: 50 suspected cases of Chronic Liver Disease determined by history, clinical examination and imaging modalities and blood investigations with age more than 12 years satisfying the criteria of CHILD PUGH – B and C were included in the study. Detailed history with presenting features was asked. Detailed general and physical examination was conducted. Icterus, Hepatic encephalopathy grading, and presence and severity of Ascites were clinically determined. All the systems were examined in detail. If connective tissue disease was clinically suspected, ANA was done by either ELISA by Euro immune ELISA kit (positive if >10 U/ml) or immunofluorescence assay. After collection of data, the forms of all patients were revised. Incomprehensible data was matched again with respective participant profile. Data was entered in MS Excel sheet for preparation of ‘Master Chart’. All the results were analysed by SPSS software. Results: The mean age of the patients was 51.32 ± 14.24 years. There was male preponderance (90%) whereas female patients constituted 10% of the study group. 34 (68%) patients suffered from Alcoholic chronic liver disease while 9 (18%) and 5 (10%) patients had chronic Hepatitis-B and chronic Hepatitis-C respectively. 2 (4%) patients had Nonalcoholic steatohepatitis. Majority of the cases of renal dysfunction (14 out of 18; 77.8%) were associated with alcoholic chronic liver disease. There was no significant association between etiology and renal dysfunction as per Chi-Square test (p>0.05). It was observed that 41(82%) were in Child Pugh B and 4 (8%) were in Child Pugh C category. 10 (24.4%) patients with Child-Pugh B classification and 8 (88.9%) patients with Child-Pugh C classification had renal dysfunction. There was significant increase in renal dysfunction with increase in the severity of liver disease as per Chi-Square test (p<0.05). Conclusion: Commonest etiology of cirrhosis found was alcohol followed by chronic hepatitis B. Renal dysfunction was found in 34% patients. Significant association was found between renal dysfunction and Child Pugh score. Key words: Chronic liver disease, Cirrhosis, Renal

 
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