Background: The choice of the optimal luting agent can be confusing, even for the most experienced clinician. Key factor to success is the choice of a proper luting agent and the cementation procedure. Hence; the present study was undertaken for comparing the impact of desensitizing agents on the retention of crowns cemented with luting agents. Materials & methods: A total of 40 freshly extracted mandibular molar teeth were selected. All the teeth were stored in normal saline till further use. All the specimens were divided into two study groups as follows: Group A: Glass ionomer cement (Control), and Group B: Glass ionomer cement (GC Tooth Mousse desensitizer). Crowns were fabricated and were subjected under universal force testing machine. All the results were recorded in Microsoft excel sheet and were analyzed by SPSS software. Results: Mean tensile bond strength of group A specimens was 42.6 Kg while mean tensile strength of Group B specimens was 43.1 Kg respectively. While comparing statistically, non-significant results were obtained. Conclusion: Application of desensitizing agents might be designated during fabrication of crowns as it will not affect the retentive ability of the luting cements. Key words: Luting agent, Desensitizing agent, Crown