Background: Diseases of the gallbladder commonly manifest as gallstones and gallbladder cancer. The prevalence of gallbladder stones varies widely in different communities in India. Hence; the present study was undertaken for assessing liver function tests in patients undergoing laparoscopic cholecystectomy. Materials & methods: 50 patients undergoing laparoscopic cholecystectomy were enrolled in the present study. A detailed work up of all the patients enrolled in the study i.e. detailed history, a thorough Clinical Examination was performed. After that all patients got their pre-anaesthetic check-up and underwent laparoscopic cholecystectomy under constant intraperitoneal pressure (12mm Hg) subsequently. In the liver function tests, following parameters were specifically studied- ALT (alanine transaminase), AST (aspartate transaminase) and Bilirubin (total). The liver function tests were repeated twice, i.e 24 hours and 72 hours after surgery to monitor liver function. All the results were analysed by SPSS software. Results: Mean AST levels during preoperative, 24 hours postoperative and 72 hours postoperative was found to be 28.5 IU/L, 76.12 IU/L and 29.71 IU/L respectively. Mean ALT levels during preoperative, 24 hours postoperative and 72 hours postoperative was found to be 29.42 IU/L, 76.41 IU/L and 30.25 IU/L respectively. Mean total bilirubin levels during preoperative, 24 hours postoperative and 72 hours postoperative was found to be 0.81 IU/L, 1.45 IU/L and 0.79 IU/L respectively. In the present study, while analysing statistically, we observed a significant transient rise in LFT profile immediate postoperatively followed by returning to normal range at 72 hours. Conclusion: There is transient rise in liver function tests postoperatively in patients undergoing laparoscopic cholecystectomy. Key words: Laparoscopic cholecystectomy, Liver function tests