Background: Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The present study was conducted to assess pancreatic manifestation in COVID-19. Materials & Methods: The present study comprised of 48 patients with COVID-19 infection of both genders. All patients were subjected to blood cytology, biochemistry, and inflammatory indicators. Pancreatic injury was defined as any abnormality in amylase and lipase level. Results: Common symptoms were fever in 90%, breathlessness in 75%, cough in 68%, fatigue in 76%, headache in 42% and diarrhoea in 38%. The difference was significant (P< 0.05). Leukocytes (X109/L) count was 5.26, neutrophils (X109/L) were 3.78, platelets (X109/L) were 195.2, monocytes (X109/L) were 0.45 and lymphocytes (X109/L) were 0.92. The mean amylase (U/L) level was 53.6, lipase (U/L) was 31.7, creatinine kinase (U/L) was 120.4, CRP (mg/L) was 36.1 and ESR (mm/ hr) was 25.9. Conclusion: COVID- 19 infection has maximum chances of pancreatic involvement even in mild cases, hence careful assessment of biochemistry is required. Key words: Amylase, COVID- 19, Pancreas