Aims & Objective: The present research was aimed for evaluating the therapeutic effectiveness of topical 70% Trichloroacetic acid effective in treating patients with seborrhoeic keratosis. Materials & methods: For the present research, analysis of 20 patients with confirmed diagnosis of SKs was enrolled. A Performa was made and clinical and demographic profile of all the patients was tabulated. Preoperative assessment was done in all the patients. Three applications of 70% TCA was done at Baseline, 2 weeks and 4 weeks. Final follow-up was done at 10 weeks. Grading of the lesions was done according to the severity of lesion. Recording of all the results was done in Microsoft excel sheet followed by analysis with SPSS software. Results: Average age of the subjects was 42.1 years. 65 percent of the patients were males while 35 percent of the patients were females. During the first visit, 80 percent of the patients had severe grade of lesions while after first application (at second visit), 60 percent of the patients had severe grade of lesions. During the third visit (4 weeks), 15 percent, 40 percent and 45 percent of the patients had mild, moderate and severe grade of lesion respectively while at the final fourth visit, 20 percent, 45 percent and 35 percent of the patients had mild, moderate and severe grade of lesion respectively. Conclusion: From the above results, the authors conclude that TCA is a safe line of treatment for treating SKs patients. Key words: Seborrhoeic keratosis, Trichloroacetic acid.