Background: The present study was conducted to assess relationship between QTc dispersion, QT dispersion and cardiac autonomic neuropathy in type-2 diabetic patients. Materials & Methods: The present study was conducted on 50 patients of type 2 diabetes mellitus of either sex. A detailed history and clinical examination was recorded in proforma of all cases. Patients were screened for cardiac autonomic neuropathy. The data so collected was compared with 25 diabetic patients without cardiac autonomic neuropathy (CAN) and 25 age and sex matched healthy individuals who will form the control group. Results: Male female ratio I group A was 1.5:1.0, in group B was 1.08:1 and in group C was 1.0:1.08, mean age in group A 52.4 years, in group B was 51.9 years and group C was 41.4, duration of diabetes was 7 years in group A, 3.76 years in group B, FBS was 171.3 mg% in group A, 151.9 mg% in group B and 97.4 mg% in group C. Abnormal Valsalva ratio was found in 16 out of 25 patients with cardiac autonomic neuropathy 64%. Conclusion: The QTcd was the parameter which had the highest accuracy in predicting patients of type 2 diabetes with cardiac autonomic neuropathy. The QTc dispersion is hence a specific marker in the diagnosis of cardiac autonomic neuropathy, which can be easily evaluated. Key words: Cardiac autonomic neuropathy, Diabetes, Valsalva ratio