Background: Many oral squamous cell carcinomas develop from potentially malignant disorders (PMDs). Several lines of evidence, including clinical, experimental and morphological data, support the concept that squamous cell carcinoma of the upper aerodigestive tract arises from noninvasive lesions of the stratified squamous epithelium. Hence, the study was undertaken to evaluate serum uric acid in oral cancer patients and patients with oral potentially malignant disorders. Materials & methods: A total of 10 patients with presence of oral cancer, 10 patients with presence of oral potentially malignant disorders and 10 healthy controls were included. All the patients were recalled in the morning and blood samples were obtained. All the samples were sent to laboratory for assessment of serum uric acid levels. All the results were recorded in Microsoft excel sheet and were analysed by SPSS software. Results: Mean uric levels among the patients of the PMD group, OSCC group and the control group were 4.82 mg/dL, 3.99 mg/dL and 5.99 mg/dL respectively. Significant results were obtained while comparing the results statistically. Conclusion: Serum uric acid levels are significantly altered in patients with PMD and oral cancer. Key words: Uric acid, Potentially malignant, Oral cancer