Background: The present study compared lorazepam and diazepam as sedative agent in oral surgical procedures. Materials & Methods: The present study was conducted on 76 patients having bilaterally impacted mandibular third molar. Patients were divided into 2 groups of 38 each. Group I were given diazepam 10 mg and group II patients were given lorazepam 2.5 mg. In all patients, Pittsburg sleep quality index and Ramsay sedation score was recorded and compared. Results: In group I there were 18 males and 20 females and in group II there were 19 males and 21 females. The mean sleep value in group I was 4.52 and was 3.06 in group II. The difference was significant (P< 0.05). The mean sedation score in group I was 3.54 and in group II was 3.78. The difference was non- significant (P> 0.05). The mean cooperation scale in group I was 1.03 and in group II was 0.74. The difference was non- significant (P> 0.05). Conclusion: Authors found that lorazepam was better as compared to diazepam in mandibular third molar surgery. Key words: Diazepam, Lorazepam, third molar surgery.