Background: Type 2 diabetes mellitus (DM2) is an important public health problem worldwide because of its high prevalence and complications. C-reactive protein (CRP), an acute phase reactant, is currently considered an independent risk factor for atherosclerosis and hypertension. The present study was planned to evaluate the concentration of Serum High Sensitivity C-Reactive protein (hs-CRP) in type-2 diabetic patients. Materials and methods: 25 type-2 diabetic patients (12 male and 13 female). These selected patients were less than 2 years duration from diagnosis of diabetes, had no complications of type-2 diabetes, no other co-morbid diseases. The mean age of the patients was 49.54±5.2 years (range 40-60 years) in male and 45.23±5.9 years (range 40-60 years) in female. The age and all other criteria matched 15 (9 male and 6 female) healthy control group who were chosen to compare with the diabetic patients. Blood samples were taken from each patient for hs-CRP, RBS and HbA1c. Results: The fasting plasma glucose of type-2 patients was 9.28 + 1.82 (Mean ± standard deviation) mmol/L, whereas the fasting plasma glucose level of normal healthy people was 6.34 ± 0.43 (Mean ± standard deviation). HbA1c (Mean ± standard deviation) of normal healthy people was 6.23 ± 1.23 and type-2 diabetic patients was 10.27 ± 4.05 hs-CRP (mg/L) level of normal healthy people and diabetic patients were 0.412 (± 0.26) and 1.48 (± 1.03) respectively. The difference in the plasma hs-CRP level between normal people and type-2 diabetic patients are significant (P<0.01). Conclusion: This higher level of mean hs-CRP  in diabetic patients is statisticaly significant (P<0.01) compared with that of the normal healthy subjects mean hs-CRP. This mean level of hs-CRP in normal healthy subjects was below the lower level of cardiovascular risk. Thus, it can be concluded that diabetic patients having higher level of mean hs-CRP level are more prone to the cardiovascular disorders as compared to normal healthy patients.
Keywords: C-reactive protein, Diabetes